Article Abstract:
Agrin, through its interaction with receptor tyrosine kinase MuSK, mediates accumulation of acetylcholine receptors (AChR) at the developing neuromuscular junction. Agrin fragment that acts as a competitive antagonist depresses action potential frequency, showing that endogenous agrin regulates native [alpha]3NKA function, and these data demonstrate that through its interaction, agrin regulates activity-dependent processes in neurons, providing a molecular framework for agrin action in the CNS.
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Article Abstract:
The kinesin superfamily member KIF4, a microtubule-based molecular motor, regulates the survival of electrically active neurons in the developing brain by modulating the function of poly(ADP-ribose)polymerase-1 in an unexpected way. The function of KIF4, which is expressed in the neonatal and juvenile but not adult brain, is obscure, but a new role is defined for KIF4 as a proapoptotic protein for developing central nervous system neurons.
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Article Abstract:
Agrin production is regulated by post-ganglionic target tissues in the chick ciliary ganglion. This protein is involved in the formation of synapses and the accumulation of the acetycholine receptor at the neuromuscular junction. Preganglionic denervation and postganglionic axotomy of chick ciliary ganglion revealed that only postganglionic axotomy significantly reduced the production of agrin.
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